Mesenchymal Stem Cells (MSCs) are multi-potent stem cells harboring multi-lineage differentiation potential and immunosuppressive properties that make MSCs an ideal candidate cell type for immunomodulation and regenerative medicine. They can change into variety of cell types, including bone, cartilage, muscle, nerve and many others. Scientists have developed proven methods for the expansion of placenta stem cells, allowing a potentially unlimited supply of this powerful resource. MSCs can be found in adipose, amnion, synovial fluid (SF), muscle, dermis, deciduous teeth and cord tissue (placenta). As the first choice for stem cell transplantation, placenta – derived MSCs appears to be the best potential.