Osteoarthritis is a chronic, non-inflammatory type of arthritis, which usually affects the movable and weight bearing joints of the body. It is the most common joint disease in human beings and common in elderly people. The aetiology of OA is not completely understood; however, injury, age, and genetics have been considered among the risk factors. OA develops because of the loss of cartilage that covers the ends of long bones within a joint. Till date, there are no safe and effective disease modifying OA drugs to treat the millions of patients suffering from this serious and debilitating disease. However, recent studies provide strong evidence for the use of mesenchymal stem cell (MSC) therapy in curing cartilage related disorders. Due to their natural multi-lineage potential, immunosuppressive activities, limited immunogenicity and relative ease of growth in culture, have attracted attentions for clinical use. From studies, Mesenchymal stem cells show promising three main healing properties. Stem cells will replace and rebuild injured cartilage with new chondrocyte, suppress inflammation with cytokines and interleukins and accelerate healing process through growth factors to improve the quality and function of the joint.